IKZF3 is a hemopoietic zinc finger DNA-binding protein that acts as a central regulator of lymphoid differentiation and is implicated in leukemogenesis.
It is a 509aa containing nuclear protein and a member of the IKAROS family of C2H2- type zinc-finger proteins and zinc finger protein, subfamily 1A with six C2H2- type zinc-fingers.
IKZF3 may form homodimers or heterodimers and is known to interact with IKZF4 and IKZF5.
A well known transcription factor, IKZF3, plays an important role in the regulation of B lymphocyte proliferation and differentiation and participates in chromatin remodeling.
IKZF3 plays a role in the control of T cell death by regulating the expression of BCL2 in acute lymphoblastic leukemia.
Strong expression of IKZF3 is usually detected in peripheral blood leukocytes, spleen and thymus and low expression in liver, small intestine, and lung.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.025-1ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human spleen lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human IKZF3/Zinc finger protein Aiolos. Species Crossreactivity: chimpanzee, rhesus monkey. Species sequence homology: bovine, canine, equine, mouse, rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa350-400 of human IKZF3.
