84-1194-97　TYRO3 (Tyrosine-protein Kinase Receptor TYRO3, BYK, DTK, FLJ16467, RSE, SKY, Tif, Tyrosine-protein Kinase byk, Tyrosine-protein Kinase DTK, Tyrosine-protein Kinase RSE, Tyrosine-protein Kinase SKY) 100ul　T9228-60C

特徴

• TYRO3 belongs to the “TAM” receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors: TYRO3, Axl, and Mer.
• TYRO3 is the primary TAM receptor detected in neurons of the central nervous system (CNS).
• TYRO3 possess at its N-terminus two immunoglobulin-like domains (Ig domains) in the extracellular part, followed by two fibronectin-type III repeats (FNIII domains).
• The membrane-spanning single helix is followed by the cytoplasmic tyrosine kinase domain.
• TYRO3 serve as a potential modulator of postsynaptic neuronal excitability and also play a role in synaptic function in the central nervous system.
• The protein is widely expressed in adult tissues, being most prominent in the brain, testis, lymphatic, kidney and vascular system.
• The pathological role of the protein has been in variety of cancers including mammary tumors, leukemia, and non-small cell lung cancer cell lines.
• Human TYRO3 gene is localized in the chromosomal region 15q15.1-q21.1.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (formalin fixed paraffin embedded): 1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.