TAAR1 is a 339aa novel membrane protein belonging to the G protein-coupled receptor family and is activated by a broad range of monoamines and amphetamine-related psychostimulants (biogenic amines).
It has two N-glycosylation sites at its N-terminus and several potential protein kinase sites at its C terminus, including two serines and a single disulfide bridge.
It shows lower cAMP accumulation in response to octopamine, tryptamine, dopamine and unresponsive to the classical biogenic amines norepinephrine, serotonin, and histamine.
It is also known to have a chemosensory function distinct from odorant receptors and is involved in functional regulation ofDT and is a potentially important target for therapeutics for methamphetamine addiction.
Recent studies demonstrated wide distribution of TAAR1 in brain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human, mouse and rat brain lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity Chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human TAAR1. Species Crossreactivity: chimpanzee. Species sequence homology: mouse, rat, monkey, bovine, opossum.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa200-230 of human TAAR1.
