The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain.
Like its counterparts in Drosophila, TLRs signal through adaptor molecules.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.
TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria.
TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
Applications:Suitable for use in Flow Cytometry and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 2-3ug/mlFlow Cytometry (intracellular): 0.5-1ug/10e6 callsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity：Recognizes mouse TLR11. Species Crossreactivity: rat.
Isotype：IgG
Calc Applications Abbrev：FC WB
Calc Crossreactivity：Mo Rt
Immunogen：Synthetic peptide corresponding to aa911-926 (CEQLKRRLSKAGQERD) of mouse TLR11 (NP_991388)
