TIM-3 has been identified as a Th1 specific marker initially due to expression on activated and polarized Th1 cells and absence on naïve T cells.
It has also been found on CD8+ T cells, Th17, Tregs , monocytes and dendritic cells.
As a transmemebrane protein, TIM-3 is also referred to as 'T cell immunoglobulin and mucin-like domain containing protein -3.' Enhanced surface expression on CD4+ and CD8+ cells in the CNS are indicative of disease in EAE, murine models of MS.
TIM-3 mediated down regulation of Th1 immune responses and induction of immune tolerance illustrate a potential key role for TIM-3 in immunoregulation.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:100-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum.
Form：Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity：Recognizes human TIM3. Species sequence homology: chimpanzee.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa176-194 (ISTLANELRDSRLANDLRD) of human TIM-3.
