TAG:TIRAP3:TICAM2 is a member of the Toll:Interleukin 1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs).
It undergoes post-translational modifications such as myristoylation and phosphorylation.
TAG is a homodimer interacting with TLR4, TICAM1, IRF3 and IRF7 in response to LPS activation.
The LPS-TLR4 signaling cascade regulates the MYD88-independent pathway during innate immune response.
It is also involved in IL-1 triggered NF-kappa-B activation.
It physically binds TLR4 and TICAM1 to transmit LPS-TLR4 signal to TICAM.
Expression of TIRAP3 appears to be essential for TLR4 signaling.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 2-4ug/mlImmunohistochemistry (formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes TAG/TIRAP3b. Species Crossreactivity: chimpanzee, bovine, mouse, opossum, rat, rhesus monkey.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Bo Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa150-200 of TAG/TIRAP3b
