84-1194-41　［取扱停止］STAT3, phosphorylated (Tyr705) (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF, FLJ20882, MGC16063) 20ug　S7971-02A

特徴

• The STAT family is a group of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.
• After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes.
• Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile (1,2).
• STAT1 and STAT3 can be activated simultaneously by the interactions of cells with the same polypeptide ligand.
• STAT3 is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
• It is activated by IL-31 through IL-31RA.
• STAT3 is known to express in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
• Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES), also known as hyper-IgE syndrome or Job syndrome.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.