84-1194-33　SOX9 (Transcription Factor SOX-9) 100ug　S5364-26A

特徴

• SOX9 has a role in sex determination and differentiation of Sertoli cells.
• It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
• Translocation of this gene can cause campomelic dysplasia.
• SOX9 is involved in the formation of testes from the indifferent fetal gonads.
• It is a major molecular component of the neuron-glia switch in developing spinal cord.
• During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium.
• These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion.
• SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative.
• It has a transcriptional regulation in melanin production in cells.
• Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 2-5ug/mlImmunohistochemistry (formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.