84-1194-27　SODD (Silencer of Death Domains, BAG Family Molecular Chaperone Regulator 4, BCL2-associated Athanogene 4, BAG4, BAG-4, DKFZp586O2022) 50ul　S2000-03

特徴

• Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas.
• Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified.
• Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors.
• A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains.
• SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling.
• TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways.
• SODD also interacts with DR3.
• SODD is ubiquitously expressed in human tissues and cell lines.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000-1:2000Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000Immunoprecipitation: 1:50-1:200Immunohistochemistry: FrozenOptimal dilutions to be determined by the researcher.
• Positive Control:Spleen, lymphoid, many cancer cell lines
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.