84-1194-05　RIP (Receptor Interacting Protein, Cell Death Protein RIP, FLJ39204, Receptor-interacting Protein 1, RIP1, RIP-1, Receptor-interacting Serine/threonine Protein Kinase 1, Receptor-interacting Serine/threonine-protein Kinase 1, Receptor (TNFRSF)-interacting Serine/threonine Kinase 1, RIPK1, Serine/threonine Protein Kinase RIP) 100ug　R2031-73Z3

特徴

• RIP1 belongs to the Ser/Thr protein kinase family and promotes apoptosis and activation of NF-kappaB.
• It associates with the intracellular domain of TNFRSF6.
• Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling.
• It plays a critical role in tumor necrosis factor-alpha (TNF-alpha)-induced I kappaB kinase (IKK) activation.
• It is also an essential component of the TLR3-Trif−mediated NF-B signaling pathway.
• RIP1 is one of the critical components involved in mediating DNA damage-induced, p53-independent cell death.
• It is expressed in tissues of intestine, small intestine, brain and testis.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Ramos cell lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.