Regulator of G-protein signaling 18; RGS13, RGS signaling proteins are highly diverse and multifunctional proteins that act as inhibitors of G-protein signaling.
RGS18, a 235aa protein, is the smallest member of this family.
It is predominantly expressed in immune tissues and is characterized by the presence of a conserved 120A.A RGS domain.
It is found to be expressed in lymphocytes, megakaryocytes and platelets and might play an important role in regulating G-protein mediated signaling in lungs and immune system.
It specifically binds to GTP-bound G-alpha subunits and acts as a GAP protein, thus inhibiting G-alpha mediated signaling.
It blocks MAP-Kinase activity and cAMP generation induced by G-alpha-i or G-alpha-q-coupled receptors.
This protein is thought to play an important role in proliferation, differentiation and migration of megakaryocytes and platelets.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:250-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum.
Form：Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity：Recognizes human RGS18. Species sequence homology: mouse and rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa111-127 (RNIQEPTETCFEEAQKI) of human RGS13.
