IPP-1 is a type 1 serine/threonine specific protein phosphatase inhibitor belonging to the protein phosphatase inhibitor 1 family.
IPP-1 has multiple domains that target cellular PP1 complexes and establishes it as a cellular regulator of eIF2alpha phosphorylation.
IPP-1 becomes active only after phosphorylation of a threonine residue by cAMP-dependent protein kinase.
It is a selective inhibitor of protein phosphatase-1 (PP1) and regulates several PP1-dependent signaling pathways, including cardiac contractility and regulation of learning and memory.
It is a widely expressed regulatory protein known to play an important role in hormonal control of glycogen metabolism.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-2ug/mlImmunohistochemistry (paraffin): 10ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human ovary lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity：Recognizes human IPP-1. Species Crossreactivity: chimpanzee, canine, equine, monkey. Species sequence homology: mouse, rat, bovine, xenopus.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Ca Eq Hu Mk Mo
Immunogen：Synthetic peptide corresponding to aa50-100 of human IPP-1.
