84-1193-64 PRAME (Melanoma Antigen Preferentially Expressed in Tumors, Opa-interacting Protein 4, OIP-4, Preferentially Expressed Antigen of Melanoma, MAPE, OIP4) 100ul P5595-50B
特徴
- PRAME is a 509aa protein belonging to the PRAME family consisting of 7 LRR (leucine-rich) repeats.
- It is a tumor antigen expressed in human melanomas and is recognized by cytolytic T lymphocytes.
- It's overexpression frequently observed in human cancers confers growth or survival advantages by antagonizing retinoic acid receptor (RAR) signaling.
- PRAME serves as a candidate marker for monitoring childhood acute leukemia.
- It is expressed in testis and acute leukemias.
- Applications:Suitable for use in Western Blot.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:1000-1:5000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for at least 12 months.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：100ul
- Host：rabbit
- Source Antibody：human
- Grade：Serum
- Purity：Serum.
- Form：Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
- Specificity：Recognizes human PRAME. Species Crossreactivity: canine and monkey. Species sequence homology: chimpanzee, bovine, equine.
- Isotype：IgG
- Calc Applications Abbrev：WB
- Calc Crossreactivity：Ca Hu Mk
- Immunogen：Synthetic peptide corresponding to aa460-510 of human PRAME
- Shelf Life：1year
- EU Commodity Code：30021010
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