NgBR, also known as Nogo-B receptor, is a 293aa rich member of the UPP synthetase family.
Though the exact function of NgBR is still not clear, reports suggest that this membrane protein acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
It has similarity with UPP synthetase proteins which suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins but has no lipid transferase activity.
NgBR colocalizes with Nogo-B during VEGF and wound healing angiogenesis and is thus able to regulate vascular remodeling and angiogenesis.
Nogo-B and NgBR mediate chemotaxis in HUVECs and induced tube formation in three-dimensional cultures.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Brain tissue lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human NgBR. Species Crossreactivity: mouse and rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa64-74 (RNRRHHRHPRG) of human Nogo-B receptor (NgBR).
