Myeloid differentiation primary response protein MyD88 is a protein which in human is encoded by the MyD88 gene.
MyD88 is a universal adaptor protein which interacts with all TLRs (except TLR3) and interleukin-1 receptors (IL-1Rs) to activate the transcription factor NF-kB.
Functional studies show that MyD88 is involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response and acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Studies suggested that MyD88-dependent TLRs and IL-1Rs are essential for protective immunity to a limited number of pyogenic bacteria and enhance the host defense to most natural infections like common viral infections.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 2-4ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human MyD88. Species Crossreactivity: mouse. Species sequence homology: chimpanzee, equine, orangutan, rhesus monkey.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa50-100 of human MyD88.
