MEIS1, also known as Homeobox protein Meis1, is a nuclear protein belonging to the TALE/MEIS homeobox family with a homeobox DNA-binding domain.
It acts as a transcriptional regulator of PAX6 (Paired box protein Pax-6).
It is a protein required for hematopoiesis, megakaryocyte lineage development and vascular patterning.
Expression is seen at low levels in normal immunohepatopoietic tissues, and in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype.
It is also expressed at high levels in the cerebellum.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 2-4ug/mlImmunohistochemistry (formalin fixed paraffin embedded): 5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Brain
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes MEIS1. Species Crossreactivity: chicken, human, monkey, mouse, rat. Species sequence homology: zebrafish, xenopus.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Ch Hu Mk Mo Rt
Immunogen：Synthetic peptide corresponding to aa170-220 of MEIS1.
