KLF4 is a protein belonging to the krueppel C2H2-type zinc-finger protein family, consisting of three C2H2-type zinc fingers.
It functions as a cell cycle checkpoint protein, induces squamous epithelial dysplasia and maintains the integrity of the G2/M checkpoint following DNA damage.
KLF4 prevents centrosome amplification following gamma radiation-induced DNA damage and plays a role in the differentiation of epithelial cells and in the development of the skeleton and kidney.
Its inactivation leads to bladder carcinogenesis and gastric carcinogenesis.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1-3ug/mlImmunohistochemistry (paraffin): 10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human KLF4. Species Crossreactivity: bovine, monkey, mouse, rat.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Bo Hu Mk Mo Rt
Immunogen：Synthetic peptide corresponding to aa1-50 of human KLF4.
