The gene encodes an EF hand-containing small calcium binding protein.
It is an integral subunit component of Kv4:D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.
Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes.
The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits.
It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface.
It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium.
It maps to 5q35.1 region of human chromosome.
Alternative splicing results in multiple transcript variant encoding different isoforms.
Isoform 1 and isoform 2 are expressed in brain and kidney.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-2ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human brain or heart
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity：Recognizes human ABP. Species sequence homology: mouse, rat, porcine, bovine.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa11-28 (LQTKQRRPSKDKIEDELE) of human ABP.
