Recently, IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines has been discovered.
IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19.
IL-23 mediates it cellular function by binding to IL-23 receptor (IL-23R), which pairs with IL-12Rb1 to confer IL-23 responsiveness.
However, human IL-12 does not bind to human IL-23R.
IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.
Applications:Suitable for use in Western Blot, Flow Cytometry and Immunohistochemistry.
Other applications have not been tested.
Recommended Dilution:Western Blot: 0.1-1ug/mlImmunohistochemistry (Paraffin): 5-10ug/mlFlow Cytometry: 1:10-1:1000Optimal dilutions to be determined by the researcher.
Positive Control:Jurkat, NIH3T3
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human IL-23R. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：FC IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor (NP_653302).
