84-1192-63　Humanin (HN) 100ul　H7953-30F1

特徴

• Humanin is a novel 24aa polypeptide identified in Alzheimer's disease-affected brain.
• It is 99% homologous to mitochondrial 16s ribosomal RNA and functions as a novel neuroprotective and cytoprotective factor.
• It specifically inhibits neuronal cell death induced by beta-amyloids and Alzheimer's disease causing FAD genes by competitively inhibiting access of FPRL1 receptor to beta-amyloids.
• It acts as an anti-apoptotic factor by binding to Bcl-2/Bax family of pro-apoptotic factors including Bax, Bak, Bid and BimEL and inhibits their pro-apoptotic activity.
• It activates JAK/STAT signaling pathway and is regulated by TRIM11.
• It interacts with IGFBP-3 and specifically blocks IGFBP-3 induced cell death in glioblastoma cells.
• Humanin is also expressed in colon and testis.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:100-1:1000Western Blot: 1:2000Optimal dilutions to be determined by the researcher.
• Positive Control:Humanin Knockout 293T Cell Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.