G-protein coupled receptor 83 (GPR83, GIR, GPR72, KIAA1540), a 423aa protein, is an orphan member of GPCR protein family and is closely related to tachykinin and NPY receptors.
It is a human homolog of mouse GIR protein and is exclusively expressed and selectively up-regulated in brain.
It is a cell surface receptor protein consisting of a putative seven-transmembrane-domain.
Reports suggest GPR83 might be involved in the regulation of immune tolerance mechanism by inducing peripheral generation of Foxp3+ Treg cells.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-1ug/mlImmunohistochemistry (frozen, formalin fixed paraffin embedded): 20ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Mouse brain lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity：Recognizes human GPR83. Species Crossreactivity: bovine, chicken, canine, mouse, rat, rhesus monkey. Species sequence homology: xenopus, chicken.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Bo Ca Ch Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa200-250 of human GPR83.
