FZD7, a 574aa protein, is a novel member of 'Frizzled' gene family.
These proteins act as transmembrane receptors for Wnt signaling proteins.
FZD7 contains an N-terminal signaling sequence, a cysteine-rich extracellular domain, 7 putative transmembrane domains and an intracellular C-terminal tail with a PDZ domain-binding motif.
FZD7 participates in cell proliferation through activation of Wnt-beta catenin-TCF pathway.
FZD7 gene expression may down-regulate APC function and enhance beta catenin-mediated signals to up-regulate genes associated with cell proliferation in human esophageal carcinomas.
Northern Blot analysis detected a ubiquitous expression of FZD7 with high expression in skeletal muscle and fetal kidney.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes mouse FZD7. Species sequence homology: rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo
Immunogen：Synthetic peptide corresponding to aa1-12 [MRGPGTAASHSPC] of mouse Fz7.
