Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.
DVL-1 is a cytoplasmic protein that regulates the stability of B-catenin in the Wnt signalling pathway.
DVL-1, the human homolog of the Drosophila dishevelled gene (dsh), encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification.
DVL-1 is a candidate gene for neuroblastomatous trans-formation.
The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL-1.
The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 5-7ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Raji calls
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Specificity：Recognizes human DVL-1. Species Crossreactivity: mouse, rat, rhesus monkey. Species sequence homology: bovIne, canine, equine.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa70-120 of human DVL-1.
