Delta-like protein 3 is a ligand for the Notch signaling pathway.
It inhibits primary neurogenesis.
DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1).
Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence.
It may be required to divert neurons along a specific differentiation pathway.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 3-5ug/mlImmunohistochemistry (Paraffin): 5ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Mouse embryo brain, T98G (human) cell lysate, human brain
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography
Form：Supplied as a liquid in PBS, 0.05% sodium azide
Specificity：Recognizes human DLL3. Species Crossreactivity: monkey and mouse
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mk Mo
Immunogen：Synthetic peptide corresponding to aa100-150 of human DLL3. Species Sequence Homology: feline; 83%, bovine; 81%, rat; 72%
