84-1191-69　DAXX (Death Domain-associated Protein 6, hDaxx, ETS1-associated Protein 1, EAP1, Fas Death Domain-associated Protein, BING2, DAP6) 50ul　D1150-05H

特徴

• Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms.
• Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas.
• Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family.
• A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx.
• Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway.
• Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000-1:2000Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000Immunoprecipitation: 1:50-1:200Immunohistochemistry: FrozenOptimal dilutions to be determined by the researcher.
• Positive Control:Prostate cancer, thymus, testes
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.