CXCR7/RDC1 is a 362aa CXC chemokine receptor involved in a number of pathobiologic processes, including cell growth, survival and adhesion, and tumor growth.
It belongs to the G-protein coupled receptor 1 family.
Though CXCR7 was previously identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered as an orphan receptor in that its endogenous ligand has not been identified.
It is an alternative receptor for CXCL12/SDF1 and ITAC (CXCL11) as well as acts as a co-receptor with CXCR4 for a restricted number of HIV isolates.
Reports suggest that CXCR7 may act as a link between inflammation and cancer.
This membrane protein is usually expressed in monocytes, basophils, and B-cells while low expression is also seen in CD4+ T-lymphocytes and natural killer cells.
Applications:Suitable for use in Western Blot, Neutralization, Immunofluorescence/Immunocytochemistry and Immunohistochemistry.
Not suitable for Flow Cytometry.
Other applications not tested.
Recommended Dilution:Western Blot: 4-6ug/mlImmunohistochemistry (FFPE): 5-10ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in Tris-Glycine, 0.05% sodium azide.
Specificity：Recognizes human CXCR7. Species Crossreactivity: mouse, rat and sheep.
Isotype：IgG
Calc Applications Abbrev：IC IF IHC N WB
Calc Crossreactivity：Hu Mo Rt Sh
Immunogen：Synthetic peptide mapping to a fragment of residues amino acids 106-129 of human CXCR7.
