Nod1 is implicated in the intracellular detection of pathogen associated molecule, such as, microbial peptidoglycans and signals the activation of NF-kB.
Nod1 has an NH2-terminal CARD-linked to a nucleotide-binding domain and a COOH-terminal segment with multiple leucine-rich repeats, which are involved in binding to multiple caspases with long prodomains, but specifically activated caspase-9 and promoted caspase-9-induced apoptosis.
Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kB activation pathways.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000-1:2500Optimal dilutions to be determined by the researcher.
Positive Control:Recombinant fusion protein
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Serum
Form：Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity：Recognizes human CARD4. Species sequence homology: mouse and monkey.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa930-949 of human Nod1.
