Apurinic:apyrimidinic (AP) sites occur frequently in DNA by spontaneous hydrolysis, DNADmaging agents or DNA glycosylases that remove specific abnormal bases.
ClassII AP endonucleases act to repair this damage by cleaving the phosphodiester backbone.
It is primarily located in the nucleus but is also present in mitochondria.
This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Positive Control:HeLa
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity Chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human APEXL2. Species sequence homology: mouse and rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptides corresponding to EELRALDSEGRALLTQHKI (aa122-140) and GQAKTSEAKDEKELRTSF (aa438-455) of human APEXL2. (Accession no. NM_014481)
