A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons.
Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families.
Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron.
Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes mouse Alivin 1. Species Crossreactivity: rat. Species sequence homology: human.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo Rt Ze
Immunogen：Synthetic peptide corresponding to aa449-464 [TGDASADDRKAGKRVV] of mouse and rat Alivin 1.
