JAB1 (Jun activation domain binding protein-1), also called COPS5 or CSN5 (COP9 signalosome-5), is a 334aa, 38kD protein that is a subunit of the COP9 signalosome complex.
It mediates cytosolic translocation of the cell cycle inhibitory protein, CDKN1B/p27Kip1, for degradation, thus promoting proliferation.
It is widely expressed, especially in proliferating cells and up-regulates granulopoiesis when overexpressed.
Within the region used as an immunogen, human JAB1 shares 99% aa identity with mouse and rat JAB1.
A 379aa isoform contains 93 alternate aa in place of the N-terminal 48aa of the 334aa form.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile PBS.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：sheep
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in PBS, PBS with 5% trehalose. Reconstitute with sterile PBS.
Specificity：Recognizes human, mouse and rat JAB1.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Recombinant corresponding to aa158-334 in human JAB1 expressed in E. coli (Q92905).
