84-1189-90　CD160 (BY55, CD160 Antigen, FLJ46513, Natural Killer Cell Receptor BY55, NK1, NK28) 100ug　C2548-88K

特徴

• CD160 (also BY55) is a 27kD member of Ig Superfamily of molecules.
• It is expressed on select hematopoietic cell types, including CD56dim CD16+cytotoxic NK cells, CD8+ CD28effectorT cells, gd T cells, and restricted CD4+ T cells.
• It is a receptor for HLAC molecules, and its engagement induces CD160+ NK cells to both secrete IFNg plus TNFg and initiate a cytotoxic program.
• Human CD160 was originally identified as a 155aa proprotein (aa27181).
• It contains a 132aa mature region (aa27159) and a Cterminal prosegment that is cleaved to create a GPI linkage.
• The mature region possesses one Vtype Ig like domain (aa27122).
• CD160 is found as a soluble, disulfidelinked 80kD multimer (likely trimer) that is generated by proteolysis of theGPIlinked form.
• This 80kD form, plus others, are highly resistant to reduction.
• There is also a 100110kD multimeric transmembrane (TM) form that is associated with activated NK cells.
• It contains a 55aa substitution for Gly180Leu181, and shows a 20aa TM segment between aa 163182.
• The TM form appears to have a splice variant that lacks aa25133.
• Over aa27159,human CD160 shares only 62% aa sequence identity with mouse CD160.
• Human CD160.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.