84-1188-90　Secretogranin-5 (Secretogranin 5, SCG5, Secretogranin V, SgV, 7B2, Neuroendocrine Protein 7B2, P7B2, Pituitary Polypeptide, Secretory Granule Endocrine Protein I, SGNE1) 50ul　S0626-05C

特徴

• Secretogranin-5 is an acidic protein of 186aa and has an expression that seems to be restricted to neurons and endocrine cells.
• In the brain, it is most abundant in the supraoptic and paraventricular nuclei of the hypothalamus.
• It acts in neuroendocrine cells as a specific chaperone for proprotein convertase-2 (PC2) which is an important endoprotease involved in the processing of neuroendocrine precursors.
• It binds to inactive proPC2 in the ER and facilitates its movement toward the secretory pathway where proPC2 is proteolytically matured and activated.
• It also plays a role in regulating pituitary hormone secretion.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:500 detected Secretogranin-5 in rat brain tissue
• Immunofluorescence: 1:200Immunohistochemistry (PAP or ABC): 1:500Optimal dilutions to be determined by the researcher.
• Amino Acid Sequence:Glu-Phe-Gly-Leu-Gln-Leu-His-Gln-His-Leu-Phe-Asp-Pro-Glu-His -Asp-Tyr-Pro-Gly-Lys-Trp-Asn-Lys-Lys-Leu-Leu-Tyr-Glu-Lys-Met -Lys-Gly-Gly-Gln
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.