84-1184-71　Inhibin, alpha (INHa) 400ug　I7652-72F

特徴

• INHA (A-inhibin subunit precursor, inhibin alpha subunit ), also called inhibin(alpha) ,which is located on chromosome 2q33-q36.
• Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH).
• Inhibin comprises of two subunits,Inhibin A and B.
• Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity.
• In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease.
• In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary.
• Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.2ug/mlOptimal dilutions to be determined by the researcher.
• AA Sequence:Ser-Thr-Pro-Leu-Met-Ser-Trp-Pro-Trp-Ser-Pro-Ser-Ala-Leu-Arg-Leu-Leu-Gln-Arg-Pro-Pro-Glu-Glu-Pro-Ala-Ala-His-Ala-Asn-Cys-His-Arg
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.