Hemopexin is a plasma protein that binds heme with the highest affinity of any known protein.
Hemopexin is generally expressed in liver, and belongs to acute phase reactants, the synthesis of which is induced after inflammation.
Heme is potentially very toxic because of its ability to intercalate into lipid membrane and to generate hydroxyl radicals.
Hemopexin’s function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin defends the body from the oxidative damage that free heme can cause.
Additionally, hemopexin discharges its bound ligand for internalization upon interacting with a specific receptor located on the surface of liver cells.
This hemopexin function is in order to preserve the body's iron.
Hemopexin’s levels in the serum are an indication of how much heme is present in the blood.
Low Hemopexin levels show that there is a lot of it in the serum.
For that reason, low hemopexin levels indicate that there has been considerable degradation of heme containing compounds - mainly hemoglobin, it indicates hemolysis and low hemopexin levels are therefore one of the diagnostic features of a hemolytic anemia.
It’s a Haem binding protein used in the assessment of intravascular hemolysis in conjunction with haptoglobin.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1mg
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM sodium phosphate, 0.15M sodium chloride, pH 7.2, 0.05% sodium azide.
