Axonal degeneration contributes to the pathogenesis of several neurodegenerative states following mechanical or neurotoxic injury.
Several studies have now demonstrated that overexpression of Nmnat1 (nicotinamide mononucleotide adenylyltransferase), a ubiquitously expressed nuclear enzyme that catalyzes an essential step in the NAD (NADP) biosynthetic pathway, has the ability to protect axons from degeneration following traumatic injury.
Applications:Suitable for use in ELISA, Immunoprecipitation, and Western Blot.
Other applications not tested.
Recommended Dilutions:ELISA: 0.5-1ug/mlWestern Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile PBS.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：sheep
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
Specificity：Recognizes human NMNAT-1.
Isotype：IgG
Calc Applications Abbrev：E IP WB
Calc Crossreactivity：Hu
Immunogen：Purified, Sf 21-derived, recombinant human NMNAT-1 (aa4-279).
