84-1174-21　LAG3 (Lymphocyte Activation Gene 3 Protein, LAG-3, Protein FDC, CD223, FDC) (PerCP) 100Tests　L1050-61M

特徴

• LAG-3, also known as CD223, is a type I membrane protein that belongs to the immunoglobulin superfamily (IGSF).
• The extracellular domain of LAG-3 contains a V-set and three C2-set Ig domains.
• LAG-3 is expressed on activated T cells, NK cells and B cells.
• It binds to MHC class II molecules with much higher avidity than CD4, a LAG-3 structural homolog.
• Mouse and human LAG-3 have been shown to be negative regulators of T cell function and homeostasis.
• The extracellular domain of human and mouse LAG-3 share 69% aa sequence identity.
• Applications:Suitable for use in Direct ELISA, Western Blot and Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: 10ul labels 1x10e6 human peripheral blood mononuclear cells (PBMCs) treated with PHA
• Optimal dilutions to be determined by the researcher.
• Absorption:482 and 564nm
• Emission:675nm
• Storage and Stability:May be stored at 4°C.
• For long-term storage, aliquot and store at 4°C.
• Do not freeze.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Further dilutions can be made in assay buffer.
• PerCP conjugates are sensitive to light.