84-1174-05　FOLR4 (Probable Folate Receptor delta, FR-delta, Folate Receptor 4, Folate-binding Protein 3, Folbp3) 100ug　F5750-19

特徴

• FOLR4 (folate receptor 4; also FR4, FR-delta and FOLBP-3) is a 35kD glycoprotein member of the folate receptor family.
• It is found on mouse Treg cells, particularly those classified as natural and CD4+ CD25- T cells that produce low amounts of IFN-gamma.
• Its function is unclear.
• Although folate family receptors can internalize folate, they are generally not the principal conduits for folate uptake.
• Mouse FOLR4 preproprecursor is 244aa in length.
• It contains a 19aa signal sequence plus a 225aa proform.
• While there are no definitive structural motifs, there is presumably a C-terminal propeptide that gives rise to a GPI-linkage.
• There are three potential isoforms.
• One is 37kD in size and shows a 36aa insertion after Glu155.
• Two others show a deletion of aa47-109, and a 17aa substitution foraa157-244.
• Over aa20-100, mouse FOLR4 shares 84% and 70% aa identity with rat and human FOLR4, respectively.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:ELISA: 0.5-1ug/ml Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile PBS.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.