PECAM-1 (platelet endothelial cell adhesion molecule1; also known as CD31) is a 130kD type I transmembrane glycoprotein adhesion molecule in the immunoglobulin superfamily.
Expression is restricted to cells involved in circulation, especially endothelial cells, platelets, monocytes, neutrophils, and lymphocyte subsets.
PECAM-1 is concentrated at cell-cell junctions and is required for trans-endothelial migration (TEM).
The extracellular domain (ECD) of PECAM-1 has ten potential N-linked glycosylation sites and six C2 type Ig like domains, the first of which is critical for adhesion and extravasation.
The cytoplasmic domain contains immunoregulatory tyrosine-based inhibitory and switch motifs (ITIM, ITSM) that mediate both inhibition and activation via phosphotyrosine-mediated engagement of SH2-containing signaling molecules.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C before opening.
DO NOT FREEZE! Stable at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
Stable for at least 12 months at 4°C.
Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
PE conjugates are sensitive to light.
仕様
Size：100Tests
Host：goat
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in sodium chloride, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
