Tyk2 belongs to the Janus tyrosine kinase family (Tyk2, Jak1, Jak2, and Jak3) that share an overall structural similarity with seven conserved domains and a sequence identity of 35–45%.
These kinases have been strongly implicated in the signal transduction of many members of the cytokine receptor family.
Tyk2 has been shown to be essential for IFN-a/b receptor function and signal transduction.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry:1:50-1:100Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human TYK2 protein around tyrosine 1054. Species Cross-Reactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic non-phosphopeptide corresponding to human TYK2 around the phosphorylation site of tyrosine 1054 (H-E-YP-Y-R).
