The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix.
TIMP4 gene contains 5 exons that span 6 kb of genomic DNA.The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues.
expressed TIMP4 inhibits MMPs in vitro.
TIMP4 gene is mapped to chromosome 3p25.
TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot:1-2ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 50% glycerol.
Specificity：Recognizes human TIMP-4. Species Cross-Reactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide mapping at the C-terminal end of human TIMP-4, different from the related mouse sequence by 3 aa.
