The synaptotagmin family has been implicated in calcium-dependent neurotransmitter release, although Synaptotagmin I (Syt I) is the only isoform that controls synaptic vesicle fusion.
Synaptotagmins have calcium-dependent membranetrafficking functions on both sides of the synapse.
Synaptotagmins also play key roles in synaptic vesicle endocytosis.
Synaptotagmin’s ability to influence both the exocytotic and endocytotic components of synaptic transmission may be modulated by its phosphorylation.
Applications:Suitable for use in Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunofluorescence:1:100-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human Synaptotagmin 1. Species Cross-Reactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：IF
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic phosphopeptide corresponding to human Synaptotagmin 1 around the phosphorylation site of serine 309 (G-L-SP-D-P).
