Synapsin is a neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is thought to function in the regulation of neurotransmitter release.
Synapsin exists as a homodimer and at the subcellular level is located at the cell junction and synapse.
It interacts with CAPON and forms a ternary complex with NOS1.
Synapsin is a substrate of at least four different protein kinases and it is likely that phosphorylation plays a role in its regulation in the nerve terminal.
Defects in SYN1 cause X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders.
Applications: Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of human Synapsin I when phosphorylated at serine 9. Species Crossreactivity: mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic phosphopeptide corresponding to human Synapsin I around the phosphorylation site of serine 9 (R-L-SP-D-S).
