84-1172-98　SOCS 1 (Suppressor of Cytokine Signaling 1, Janus kinase (JAK) binding protein, STAT-induced STAT inhibitor, SSI-1, Cish1, Ssi1) 100ug　S1040-01J

特徴

• Suppressor of cytokine signaling 1 (SOCS1), also known as Jak-binding protein (JAB), is a negative regulator to a subset of protein-tyrosine kinases.
• This 211aa protein has a molecular mass of about 23.5kD.
• The TEC-binding region of SOCS1 resides in the N terminus.
• SOCS1 associates with Tec and suppresses its kinase activity.
• The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13.2 SOCS1 regulates the JAK/STAT signal-transduction pathway.
• Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot:1-2ug/ml Immunohistochemistry (paraffin): 0.5-1ug/ml Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile dH20.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.