84-1172-85　［取扱停止］SHP2, phosphorylated (Tyr542) (SH2 Domain-containing Protein Tyrosine Phosphatase 2, SHP-2, BPTP3, BPTP-3, CFC, MGC14433, Noonan Syndrome 1, Noonan Syndrome 1 Protein Tyrosine Phosphatase 2C, NS1, Protein Tyrosine Phosphatase 2C, PTP2C, PTP-2C, Protein Tyrosine Phosphatase Non-receptor Type 11, PTPN11, PTP1D, PTP-1D, SHIP2, SHPTP2, SH-PTP2, SHPTP3, SH-PTP3, SIT Protein Precursor, Syp, Tyrosine ...　S1013-30P

特徴

• The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity.
• Shp2 can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation.
• Shp2 is specifically required in mesenchyme cells of the progress zone (PZ), directly beneath the distal ectoderm of the limb bud.
• Rather than integrating proliferative signals, Shp2 probably exerts its effects on limb development by influencing cell shape, movement or adhesion.
• Furthermore, the branchial arches, which also use Fgfs during bud outgrowth, similarly require Shp2.
• Thus, Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.