84-1171-56　NMDA 1 Receptor (N-methyl-D-aspartate, NMDAR1) 50ug　N2904-35F1

特徴

• The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor.
• NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors.
• Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes.
• NMDAR1 gene is mapped to 9q34.3 and encodes a 938aa protein which showed high evolutionary conservation in structure and physiologic properties.
• It consists of 21 exons distributed over about 31kb.
• Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence.
• The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'.
• The gene is a candidate for the site of the mutation in torsion dystonia.
• The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell.
• NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.