- アズワンのAXELショップ
- 試薬
- 特定メーカー試薬
- US Biological（antibodypab）
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84-1170-49 ［取扱停止］IKK beta, phosphorylated (Tyr199) (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB Kinase 2, Inhibitor of kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor kappa B Kinase beta, MGC131801, Nuclear Factor NFkB Inhibitor Kinase beta, NFKBIKB, Nuclear Factor of kappa Light Chain Gene Enhancer in B cell ... I3000-27G
84-1170-49 ［取扱停止］IKK beta, phosphorylated (Tyr199) (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB Kinase 2, Inhibitor of kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor kappa B Kinase beta, MGC131801, Nuclear Factor NFkB Inhibitor Kinase beta, NFKBIKB, Nuclear Factor of kappa Light Chain Gene Enhancer in B cell ... I3000-27G
特徴
- IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP.
- Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination.
- IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta.
- Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1.
- Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response.
- Additionally, IKK-beta activity can also be regulated by MEKK-1.
- Applications:Suitable for use in Immunofluorescence.
- Other applications not tested.
- Recommended Dilution:Immunofluorescence:1:100-1:200 Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for at least 12 months.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：50ug
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
- Specificity：Recognizes IKK-beta when phosphorylated at tyreonine 199. Species Cross-Reactivity: human, mouse, rat.
- Isotype：IgG
- Calc Applications Abbrev：IF
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Synthetic phosphopeptide corresponding to human IKK-beta around the phosphorylation site of tyrosine 199 (Q-K-YP-T-V).
- Shelf Life：1year
- EU Commodity Code：30021010
- 商品名：IKK beta, phosphorylated (Tyr199) (IkappaB Kinase beta, IKKb, IKK2, IkBKb, IkappaB Kinase 2, Inhibitor of kappa Light Chain Gene Enhancer in B cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B cells Kinase beta, Inhibitor of Nuclear Factor kappa B Kinase beta, MGC131801, Nuclear Factor NFkB Inhibitor Kinase beta, NFKBIKB, Nuclear Factor of kappa Light Chain Gene Enhancer in B cells Inhibitor) 50ug
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