Dopamine receptor D1, also known as DRD1, is a human gene.
It is the most highly expressed DA receptor subtype among the DA receptor family.
Receptors for dopamine have been classified into two functional types, D1 and D2.
They belong to the family of receptors acting through G (or guaninenucleotide-binding) proteins.
D2 receptors inhibit adenylyl cyclase, but D1 receptors stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases.
Dopamine D1 and D2 receptors are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism.
D1 receptors regulate neuron growth and differentiation, influence behavior and modify dopamine D2 receptor-mediated events.
And the presence of a D1 receptor gene restriction fragment length polymorphism will be helpful for future disease linkage studies.
DRD1 also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot:1ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
Specificity：Recognizes human DRD1. Species Cross-Reactivity: mouse, rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to a sequence at the C-terminal of human DRD1, identical to the related rat and mouse sequence.
