84-1168-76　［取扱停止］Cyclin E1 (G1/S-specific Cyclin-E1, CCNE1, CCNE) 50ug　C8455-26F

特徴

• Cyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2.
• Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase.
• The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication.
• Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells.
• Abnormally high levels of cyclin E expression have frequently been observed in human cancers.
• Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.