84-1167-40　AMD1 (SAMDC , S-adenosylmethionine Decarboxylase Proenzyme, AdoMetDC, S-adenosylmethionine Decarboxylase alpha Chain, S-adenosylmethionine Decarboxylase beta Chain, AMD1, AMD) 100ug　A1372-24C

特徴

• S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC), is a key enzyme in polyamine biosynthesis.
• It is localized to chromosome region 6q21-q22.
• SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin.
• It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool.
• SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target.
• Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.1-0.5ug/ml Immunohistochemistry (Paraffin): 0.5-1ug/ml.
• Antigen retrieval by heat is required
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile dH20.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.