84-1167-01　STXBP1 (Syntaxin-binding Protein 1, N-Sec1, Protein unc-18 Homolog 1, Unc18-1, Protein unc-18 Homolog A, Unc-18A, p67, UNC18A) 100ug　S9205-80

特徴

• STXBP1 (Syntaxin-binding protein 1; also p67, Munc18-1, N-Sec1 and Unc18A) is a 67kD member of the SNARE-interacting Sec1/Unc18/STXBP family of proteins.
• It is expressed in a variety of cells, presumably in those that exhibit granule exocytosis, and likely participates in (synaptic) granule release.
• Ligands for STXBP1 include STX1A, 2 and 3, and it is possible that STXBP1 both suppresses STX activity, and serves as an anchor for STX-mediated vesicle fusion.
• Human STXBP1 is 594aa in length.
• It contains one SEC1 domain (aa41-575).
• Phosphorylation at Ser313 may stimulate granule release.
• There is one splice variant that shows a 28aa substitution for aa576-594.
• This is restricted to neural tissue.
• Over aa80-226, human and mouse STXBP1 are absolutely identical in amino acid sequence.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.